Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]q

Details Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]q Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]q

1995-05-31

1997-08-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 41, A61K 3147

Patent

active

056589204

ABSTRACT:
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.

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