Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1986-11-21
1988-11-15
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 22, 536 26, C07H 1923, C07H 504, C07H 19044
Patent
active
047850850
ABSTRACT:
There are disclosed analogs of the antitumor agent, rebeccamycin, which possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin produced by first reacting rebeccamycin with a strong base to obtain a reactive intermediate and then reacting the reactive intermediate with an aminoalkyl compound.
REFERENCES:
patent: 4487925 (1984-12-01), Nettleton, Jr. et al.
patent: 4552842 (1985-11-01), Nettleton, Jr. et al.
Organic Chemistry, 2nd Edition, D. J. Cram & G. S. Hammond, McGraw-Hill Book Co., N.Y., 1964.
D. E. Nettleton et al., Tetrahedron Letters, 26 (34), 4011-4014 (1985), "Isolation and Structure of Rebeccamycin-A New Antitumor Antibiotic From Nocardia Aerocolonigenes."
T. Kaneko et al., ibid, 26i(34), 4015-4018(1985), "Two Synthetic Approaches to Rebeccamycin."
Kaneko Takushi
Utzig Jacob J.
Wong Henry S.
Bristol-Myers Company
Crane L. Eric
Griffin Ronald W.
Morse David M.
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