Heavy metal salts of hyaluronic acid and their use as antimicrob

Details Heavy metal salts of hyaluronic acid and their use as antimicrob Heavy metal salts of hyaluronic acid and their use as antimicrob

1987-03-09

1988-11-15

Richman, Barry S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 21, 514495, 514500, 424 65, 424 95, A61K 732, A01N 6302

Patent

active

047849916

ABSTRACT:
Heavy metal salts of hyaluronic acid have been prepared. In particular, this invention is directed to silver, gold, cerium and tungsten salts of hyaluronic acid. These heavy metal salts of hyaluronic acid are useful as antimicrobial agents. Gold hyaluronate may also be used to treat arthritis.
This invention also concerns methods of making the silver salt of hyaluronic acid as well as compositions containing silver hyaluronate or gold hyaluronate.
The invention also concerns composition containing heavy metal salts having radioactively labelled hyaluronate moieties.

REFERENCES:
patent: 4172128 (1979-10-01), Thiele et al.
patent: 4211769 (1980-07-01), Okado et al.
patent: 4487865 (1984-12-01), Balazs et al.
patent: 4605691 (1986-08-01), Balazs et al.
"Cu.sup.+2 Hyaluronic Acid Complex:Spectrophotometric Detection", Figueroa et al, Biochemical and Biophysical Research Communications 74(2), 460-465, 1975.
"Hyaluronic Acid Conformations Observed for Various Salt Forms in the Crystaline Phase", Atkins et al., Connective Tissue Research 62(2), 116, (1978).

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