GRF analogs VI

Details GRF analogs VI GRF analogs VI

1987-06-10

1988-11-15

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3743, C07K 710

Patent

active

047849878

ABSTRACT:
The invention provides peptides which are potent in stimulating the release of pituitary GH in fish and amphibians which have a substantial portion or all of the following sequence: R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 -R.sub.5 -Phe-R.sub.7 -R.sub.8 -R.sub.9 -Tyr-Arg-R.sub.12 -R.sub.13 -Leu-R.sub.15 -Gln-Leu-R.sub.18 -Ala-Arg-Lys-R.sub.22 -Leu-R.sub.24 -R.sub.25 -R.sub.26 -R.sub.27 -R.sub.28 -R.sub.29 -R.sub.30 -R.sub.31 -Gly-R.sub.33 -R.sub.34 -R.sub.35 -R.sub.36 -R.sub.37 -R.sub.38 -R.sub.39 -R.sub.40 -R.sub.41 -R.sub.42 -R.sub.43 -R.sub.44 -Ser wherein R.sub.1 is N-Me Tyr, Tyr, desNH.sub.2 -Tyr, D-Tyr, N-Et Tyr, N-Ip Tyr, N-Me His, His, desNH.sub.2 -His, D-His, N-Et His, and N-Ip His; R.sub.2 is Ala, D-Ala or D-NMA; R.sub.3 is Asp or D-Asp; R.sub.4 is Gly or Ala; R.sub.5 and R.sub.27 are selected from the group consisting of Met, Leu, Val, Nva, Gln, Thr, Ile, Ala, Arg, Asn, Asp, Cys, Glu, Gly, His, Nle, Lys, Phe, Pro, Ser, Tyr and Trp; R.sub.7 is Asn or Thr; R.sub.8 is Lys, Asn or Ser; R.sub. 9 is Ala or Ser; R.sub.12 is Lys or Arg; R.sub.13 is Ala, Val or Ile; R.sub.15 is Gly or Ala; R.sub.18 is Ser or Tyr; R.sub.22 is Tyr or Leu; R.sub.24 is His or Gln; R.sub.25 is Thr, Asp, or Glu; R.sub.26 is Leu or Ile; R.sub.28 is Ala, Ser or Asn; R.sub.29 is Lys or Arg; R.sub.30 is Arg or Gln; R.sub.31 is Val or Gln; R.sub.33 is Gly or Glu; R.sub.34 is Gly, Arg or Ser; R.sub.35 is Ser or Asn; R.sub.36 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R.sub.37 is Ile or Glu; R.sub.38 is Glu, Gln or Arg; R.sub.39 is Asp, Arg or Gly; R.sub.40 is Asp, Ser or Ala; R.sub.41 is Asn, Arg or Lys; R.sub.42 is Glu, Phe, Ala or Val; R.sub.43 is Pro, Asn or Arg; R.sub.44 is Leu or Ala; provided however that at least one of the following is present: R.sub.7 is Asn, R.sub.8 is Lys, R.sub.13 is Ala, R.sub.22 is Tyr and R.sub.25 is Thr; and provided further that any or all of the residues after R.sub.27 may be deleted. A 29-residue peptide beginning at the N-terminus may be preferred. These peptides, as well as their nontoxic salts, are considered to be particularly useful in aquiculture.

REFERENCES:
patent: 4689318 (1987-08-01), Kaiser et al.

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