Medical crosslinked polymer gel of carboxylic polysaccharide and

Details Medical crosslinked polymer gel of carboxylic polysaccharide and Medical crosslinked polymer gel of carboxylic polysaccharide and

1996-01-16

1997-08-19

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514944, 2523153, 2523154, A61K 910

Patent

active

056585926

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

This is a National Stage Application of PCT/JP95/00873 filed May 8, 1995.
The present invention relates to a medical polymer gel. More specifically, the present invention relates to a novel medical polymer gel having a drug releasing property. The medical polymer gel of the present invention is useful as the structural component for wound dressings, adhesives for biological tissues, adhesion preventing agents, bone reinforcing materials, and drug releasing base materials.
The present invention also relates to a novel water swelling polymer gel consisting of polysaccharide having excellent transparency, thermal resistance, biocompatibility and stability. The water swelling polymer gel provided by the present invention is useful as the structural component of medical polymer gels and also useful as the structural component of medical materials such as wound dressings, adhesion preventing agents and adhesives for biological tissues because the polymer gel itself has excellent thermal resistance and biocompatibility. Furthermore, because the polymer gel has excellent transparency, the polymer gel is useful as the structural component of wound dressings and adhesion preventing agents, in particular.


BACKGROUND ART

In the present specification, the term "water swelling polymer gel" means a polymer gel, being capable of swelling in body fluids such as blood, plasma and intercellular fluid or fluids similar to body fluids, and having biocompatibility. As such water swelling polymer gel consisting of polysaccharide, it is known a gel composed of agar, agarose and carrageenan. Chemically crosslinked dextran or cellulose gel, calcium-ion crosslinked alginate gel, and a gel composed of chitin or chitosan are also known.
The application of water swelling polymer gels to medical practice is exemplarily found in wound dressings, contact lens, intraocular lens, adhesives for biological tissues, adhesion preventing materials, adsorbents for blood purification, hybrid artificial organs such as artificial pancreas and artificial liver, artificial cartilage, base materials for releasing drugs in a sustained manner and the like. Because water swelling polymer gels have compositions and mechanical properties similar to those of biological tissues, such gels may be applied in a wide variety of fields in the future.
Gauze and ointments have been used conventionally for treating wounds such as injury and burn, ulcer, and decubitus. These have effects of absorbing exudates and preventing the penetration of exogenous bacteria and the like. It has been indicated recently that a variety of growth factors (bFGF, TGF.beta., etc.) promoting wound healing are present in the exudates from the wounds (see Howell, J. M., Current and Future Trends in Wound Healing, Emerg. Med. Clin. North Amer., 10, 655-663 (1992)). Therefore, attention has been focused on an occlusive dressing having the effect of promoting wound healing while holding the growth factor on the wound (Eaglstein, W. E., Experience with biosynthetic dressings, J. Am. Acad. Dermatol., 12, 434-440 (1985)).
As the occlusive dressings, use may be made of polyurethane film, hydrocolloid, non-woven fabric of alginate fiber, polyvinyl alcohol sponge, and water swelling polymer gels comprising polyethylene glycol and polyacrylamide.
As such adhesive for biological tissues, use may be made of cyanoacrylate polymerizable adhesives, fibrin glue and the like.
As adhesion preventing agents, those composed of oxycellulose mesh are known.
As the method for producing these water swelling polymer gels, it is known a method of producing solid matters of amylose, dextran or pullulan, crosslinked with succinate or glutarate (see the Specification of U.S. Pat. No. 4,002,173). These are preferable as a hemostatic agent. Also, it is known crosslinked chitosan produced by reacting chitosan with N-hydroxysuccinimide ester (see Japanese Patent Laid-open No. Hei 2-180903). This is useful in the field relating to medicines, such as artificial skins. Furthermore, viscous and elastic flui

REFERENCES:
patent: 4452892 (1984-06-01), Rosevear

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