Phosphono-hydroisoquinoline compounds useful in reducing neuroto

Details Phosphono-hydroisoquinoline compounds useful in reducing neuroto Phosphono-hydroisoquinoline compounds useful in reducing neuroto

1992-10-05

1995-01-31

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

546 23, C07F 960, C07F 962, A61K 31675

Patent

active

053858956

ABSTRACT:
A class of phosphono-hydroisoquinoline compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phosphono-hydroisoquinoline compound alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1 through R.sup.4 is hydrido, each of Z.sup.1 and Z.sup.2 is hydroxyl and wherein the A ring is saturated.

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