Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Patent
1996-07-30
1997-08-19
Gorgos, Kathryn L.
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
204601, G01N 2726, G01N 27447
Patent
active
056584466
ABSTRACT:
A wide-bore capillary electrophoresis apparatus for the analysis of analyte ions is provided. The apparatus has a wide-bore capillary that has a restriction zone at one or more ends. The capillary has an inlet end and an outlet end and an opening at each of said ends. The restriction zone is capable of providing fluid communication between the wide bore and the opening at said end. The restriction zone includes a narrow bore extending to the opening and a transition zone providing gradual change of bore diameter from the wide bore to the narrow bore. The apparatus further has a buffer source to supply buffer to the inlet end of the capillary and a power supply for supplying power to drive buffer and analyte ions through the capillary. During CE, electrodes provide electrical communication between the power supply and the inlet end and the outlet end and apply a voltage differential between said ends.
REFERENCES:
patent: 5061361 (1991-10-01), Gordon
patent: 5092973 (1992-03-01), Zare et al.
patent: 5324413 (1994-06-01), Gordon
A. Cifuentes et al, "Rectangular Capillary Electrophoresis: Study of Some Dispersive Effects" Journal of Chromatography A, 737*(1996) 243-253.
Henrik T. Rasmussen et al, "Influence of Buffer Concentration, Capillary Internal Diameter and Forced Convection on Resolution in Capillary Zone Electrophoresis" Journal of Chromatography, 516*(1990) 223-231.
Tsukagoshi Kazuhiko et al, "Performance of a Coiled Capillary on One-cm Diameter in Capillary Electrophoresis" Analytical Sciences, vol. 12 (Oct. 1996) 811-814.
Kevin D. Altria, "Micro-Preparative Applications of Capillary Electrophoresis" Isolation & Purification, vol. 2 (1996) 113-125.
Y. Chen & An Zhu, "Flat Capillary Zone Electrophoresis" Science in China (Series B) vol. 35, No. 6 (Jun. 1992) 649-658.
Kevin D. Altria, "Optimization and Improvement of Sensitivity in Capillary Electrophoresis for Quantitation of Selected Pharmaceutials" LC-GC, vol. 11 No. 6 (Jun. 1993) 438-442.
Huey G. Lee, "Optimization of the Loading Limit for Capillary Zone Electrophoresis of Synthetic Opioid and Tachykinin Peptides: a Study of the Interactions Among the Amount of Peptide, Resolution, Saturation, Injection Volume and Capillary Diameter" Journal of Chromatography B, 662 *(1994) 35-45.
Keely et al. Dec. (1994) "Modeling Flow Profiles and Dispersion in Capillary Electrophoresis with Nonuniform Potential", Analytical Chemistry, 66(23), pp. 4236-4242.
Datta et al. Jun. (1990) "Electrokinetic Dispersion in Capillary Electrophoresis", AIChE Journal, 36(6), pp. 916-926.
Brown et al. No month available (1975) "Electrophoretic Thermal Theory II. Steady-State Radial Temperature Gradients in Circular Section Columns", J. of Chromatography 109, pp. 218-224.
R. Aris. (1995) No month available "On the Dispersion of a Solute in a Fluid Flowing Through a Tube", Dept. of Chem, Eng., Univ. of Minnesota, pp. 67-77.
Holloway Robert R.
Keely-Templin Catherine A.
McManigill Douglass
Yin Hongfeng
Gorgos Kathryn L.
Hewlett--Packard Company
Starsiak Jr. John S.
LandOfFree
Preparative capillary electrophoresis with wide-bore capillary does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparative capillary electrophoresis with wide-bore capillary, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparative capillary electrophoresis with wide-bore capillary will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1102086