Amines coupled wth dicyclic dianhydrides capable of being radiol

Details Amines coupled wth dicyclic dianhydrides capable of being radiol Amines coupled wth dicyclic dianhydrides capable of being radiol

1982-07-26

1984-10-30

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

260429J, 424 9, A61K 4300, A61K 4900

Patent

active

044799306

ABSTRACT:
A dicyclic dianhydride rapidly and efficiently couples with a broad variety of amines such as polypeptides and proteins in non-aqueous or aqueous media and then may be chelated with a wide choice of radioisotope metallic cations to yield a radio-labeled product that is stable in vivo. A simple 1-step synthesis of the coupled amine in aqueous solution of neutral pH is described which requires only a few minutes time and with little accompanying hydrolysis.

REFERENCES:
patent: 4385046 (1983-05-01), Milbradt et al.
Hnatowich et al., Int. J. Appl. Radiat. Isot., 33:327-332 (1982).

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