Method for using purine derivatives

Details Method for using purine derivatives Method for using purine derivatives

1982-10-14

1986-09-02

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544276, 544277, 435119, C07D47318, A61K 3152

Patent

active

046096620

ABSTRACT:
The novel 2-aminopurine derivatives disclosed herein which have a hydrogen atom in the 6-position and an acyclic chain ##STR1## in the 9-position [wherein X=O or S, Y=H or CH.sub.2 OR and R=H or ##STR2## wherein R.degree.=H, C.sub.1-16 alkyl (preferably C.sub.1-6 alkyl), optionally substituted aralkyl or optionally substituted aryl, provided at least one R is ##STR3## are converted in vivo by the action of xanthine oxidase/dehydrogenase or aldehyde oxidase and esterase enzymes into the corresponding 6-hydroxy compounds wherein R=H, which are potent antiviral compounds.

REFERENCES:
patent: 4146715 (1980-04-01), Schaeffer
patent: 4199574 (1980-05-01), Schaeffer
patent: 4323573 (1982-04-01), Schaeffer
patent: 4340726 (1982-07-01), Simon et al.
patent: 4347360 (1982-08-01), Ogilvie
patent: 4355032 (1982-10-01), Verheyden et al.
patent: 4423050 (1983-12-01), Verheyden et al.

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