Process of and material for stimulating growth of cartilage and

Details Process of and material for stimulating growth of cartilage and Process of and material for stimulating growth of cartilage and

1984-03-20

1986-09-02

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435240, 435241, 514 2, 623 16, 623 66, A61K 3532, A61F 228

Patent

active

046095519

ABSTRACT:
A process for exposing live cells to a soluble bone protein and transferring the cells into appropriate skeletal sites to initiate or enhance local chondrogenesis or osteogenesis. Isogenic fibroblasts are exposed in vitro to a soluble bone protein capable of stimulating in vitro and/or in vivo a chondrogenic response. The fibroblasts are then transferred in vivo in a manner effective to prevent diffusion away from the implantation site so that the desired chondro/osteogenesis reaction can proceed. Delivery systems include: combining the activated fibroblasts with a biodegradable matrix; suspending the activated fibroblasts in a solution suitable for intra-articular injection; and attaching the fibroblasts to allografts and prosthetic devices.

REFERENCES:
patent: 4294753 (1981-10-01), Urist
patent: 4456687 (1984-06-01), Green

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