Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters

Details Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters

1984-07-02

1987-04-07

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544116, 544166, 544286, 544395, C07D41304, C07D40304, C07D23980

Patent

active

046562672

ABSTRACT:
The synthesis of substituted 2(1H)-quinazolinone-1-alkanoic acids and their esters is described. The novel quinazolinones are renal vasodilators and as such reduce vascular resistance to renal blood flow. The quinazolinones are useful as cardiovascular agents.

REFERENCES:
patent: 4001238 (1977-01-01), Partyka et al.
patent: 4146712 (1979-03-01), Yamamoto et al.
patent: 4490374 (1984-12-01), Bandurco et al.
patent: 4555570 (1985-11-01), Kanojia et al.
patent: 4555571 (1985-11-01), Bandurco et al.
Lucas, Organic Chemistry, Sec. Ed., 1953, American Book Co., New York, pp. 211-215.
Morrison et al, Organic Chemistry, Sec. Ed., 1966, Allyn and Bacon, Inc., Boston, pp. 969-971.

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