Pharmaceutical compositions containing .beta.-lactam antibiotics

Details Pharmaceutical compositions containing .beta.-lactam antibiotics Pharmaceutical compositions containing .beta.-lactam antibiotics

1987-06-04

1989-02-07

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514192, 514197, 514199, 514200, 514203, 514204, A61K 3143, A61K 31545

Patent

active

048031968

ABSTRACT:
A solid pharmaceutical composition comprising one or more .beta.-lactam antibiotics in acid or amphoteric form in association with at least one physiologically acceptable base in the presence of a gaseous atmosphere containing a stabilizing amount of carbon dioxide at a concentration greater than that of atmospheric air. The compositions exhibit enhanced stability. A preferred antibiotic for the compositions is ceftazidime or a hydrate thereof, and a preferred base is sodium cabonate or a mixture thereof with one or more other bases.

REFERENCES:
patent: 4128715 (1978-12-01), Sharp
patent: 4160829 (1979-07-01), Heisboer et al.
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4329453 (1982-05-01), Brodie et al.
Remington's Pharmaceutical Sciences, Philadelphia College of Pharmacy and Science, 1980, pp. 1480-1481.

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