N-alkylguanine acyclonucleosides as antiviral agents

Details N-alkylguanine acyclonucleosides as antiviral agents N-alkylguanine acyclonucleosides as antiviral agents

Filed on

1984-04-06

Date issued

1986-04-01

Examiner

Rizzo, Nicholas S.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

544276, 544277, C07D47318, A61K 3152

Type

Patent

Status

active

Patent number

045798494

Description

ABSTRACT:
Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R.sup.1 and R.sup.2 are independently alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, each having 1 to 19 carbon atoms, or R.sup.2 is hydrogen; R.sup.3 is hydrogen, alkyl having 1 to 6 carbon atoms or hydroxyalkyl having 1 to 6 carbon atoms; R.sup.4 is hydrogen, halogen, amino or alkyl having 1 to 4 carbon atoms; R.sup.5, R.sup.6 and R.sup.7 are independently selected from hydrogen, hydroxy, alkyl having 1 to 6 carbon atoms, acyloxy having 1 to 8 carbon atoms, alkoxy having 1 to 6 carbon atoms, hydroxyalkyl having 1 to 6 carbon atoms, acyloxyalkyl having 1 to 12 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms and --PO.sub.3.sup.=, or two of R.sup.5, R.sup.6 and R.sup.7 taken together form a group --OPO.sub.2 O.sup.- --, --CH.sub.2 OPO.sub.2 O.sup.- --, --CH.sub.2 OPO.sub.2 OPO.sub.2 O.sup.= --, or --OPO.sub.2 OPO.sub.2 O.sup.= --; A is O, S or CH.sub.2 and X is a pharmaceutically acceptable anion. The compounds have antiviral activity, especially against viruses of the herpes class.

REFERENCES:
patent: 4323573 (1982-04-01), Schaeffer
patent: 4347360 (1982-08-01), Ogilive
patent: 4461757 (1984-07-01), Ogilive
Weber, et al., J. Biol. Chem., vol. 251, No. 18, pp. 5657-5662 (1976), entitled "Inhibition of HeLa Cell Messenger RNA Translation by 7-Methylguanosine 5'-Monophosphate".

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