Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-11-19
1986-04-01
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514222, 514322, 514253, 548422, 2602457, 544 585, 544142, 546199, A61K 3140, C07D40304
Patent
active
045797374
ABSTRACT:
Symmetrical bis-amidine derivatives of mitomycin C may be converted to unsymmetrical bis-amidine analogs by reaction with secondary amines. The compounds are active anti-tumor agents in experimental animal tumors.
REFERENCES:
patent: 3121084 (1964-02-01), Winberg
patent: 3332944 (1967-07-01), Cosulich et al.
patent: 3420846 (1969-01-01), Matsui et al.
patent: 3450705 (1969-06-01), Matsui et al.
patent: 3514452 (1970-05-01), Matsui et al.
patent: 3660578 (1972-05-01), Hata et al.
patent: 4231936 (1980-11-01), Nakano et al.
patent: 4268676 (1981-05-01), Remers
patent: 4487769 (1984-12-01), Vyas et al.
Webb et al., JACS, vol. 84 (1962), pp. 3185-3187.
Matsui et al., J. Antibiotics, vol. XXI (1968), pp. 189-198.
Kinoshita et al., J. Med. Chem., vol. 14 (1971), pp. 103-109.
Sandler et al., Org. Chem., vol. 12 (1972), pp. 227 and 228.
Abdulla et al., Tetrahedron, vol. 35 (1979), pp. 1720-1724.
Iyengar et al., J. Med. Chem., vol. 24 (1981), pp. 975-981.
Iyengar et al., Abstracts of Papers, Annual Meeting of the American Chemical Society, Las Vegas, Mar. 1982, #MEDI 72.
Doyle Terrence W.
Kaneko Takushi
Vyas Dolatrai M.
Bristol-Myers Company
Carnahan Robert E.
Kight John
Moore M. L.
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