Esculetin derivatives and pharmaceutical composition

Details Esculetin derivatives and pharmaceutical composition Esculetin derivatives and pharmaceutical composition

1994-03-02

1995-10-03

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549285, 514825, A61K 3135

Patent

active

054552680

ABSTRACT:
A pharmaceutical composition comprising a compound of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom, a saturated or unsaturated aliphatic acyl having 2 to 25 carbon atoms or benzoyl group and R.sup.3 is a hydrogen atom or alkyl group, and a pharmaceutically acceptable carrier is disclosed. Further, a novel compound of the general formula (I) wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom, pivaloyl, capryloyl, lauroyl, palmitoyl, stearoyl, linoleoyl, docosahexaenoyl, or benzoyl group, and R.sup.3 is a hydrogen atom or methyl group, is also disclosed.

REFERENCES:
Chandratre et al., "Studies in Synthesis of Furocoumarins: Part XXVIII--Synthesis of Difuranocoumarins," Indian J. Chem., vol. 268, No. 12, pp. 1148-1150 (Dec. 1987).
Nagarajan et al., "Coumarins of Fraxinus floribunda," Indian J. Pharm. Sci., vol. 46, No. 5, pp. 176-177 (1984).
Chemical Abstracts, vol. 76, No. 15, Abstract No. 81680r (1972).
Chemical Abstracts, vol. 100, No. 27, Abstract No. 6270t (1984).
Chemical Abstracts, vol. 99, Abstract No. 187316 (1983).
Chemical Abstracts, vol. 99, Abstract No. 187317 (1983).
Chemical Abstracts, vol. 99, Abstract No. 18718 (1983).

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