Process for making chiral alpha-amino phosphonates and selected

Details Process for making chiral alpha-amino phosphonates and selected Process for making chiral alpha-amino phosphonates and selected

1995-03-14

1997-08-05

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558 87, 558142, 560 27, 562 15, 562 16, C07F 940, C07F 938

Patent

active

056544626

ABSTRACT:
This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiotics and/or as intermediates in the preparation of phosphorus-containing analogs of peptides, i.e., phosphonopeptides or pseudopeptides having known uses, such as in antibiotics, antibiotic enhancers, or enzyme inhibitors.

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