Insulin-like growth factor agonist molecules

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530300, 530303, 530321, 530324, 530325, 530327, 530328, 514 12, 514 13, 514 14, 514 15, C07K 1400, C07K 1465, A61K 3804, A61K 3816

Patent

active

061214167

ABSTRACT:
Compounds are provided that prevent the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal

REFERENCES:
patent: 4411890 (1983-10-01), Momany
patent: 4876242 (1989-10-01), Applebaum
patent: 4988675 (1991-01-01), Froesch et al.
patent: 5068224 (1991-11-01), Fryklund et al.
patent: 5077276 (1991-12-01), Ballard et al.
patent: 5093317 (1992-03-01), Lewis et al.
patent: 5106832 (1992-04-01), Froesch et al.
patent: 5126324 (1992-06-01), Clark et al.
patent: 5164370 (1992-11-01), Ballard et al.
patent: 5187151 (1993-02-01), Clark et al.
patent: 5202119 (1993-04-01), Clark et al.
patent: 5206235 (1993-04-01), Fisher et al.
patent: 5210017 (1993-05-01), Carlsson et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5273961 (1993-12-01), Clark
patent: 5374620 (1994-12-01), Clark et al.
patent: 5466670 (1995-11-01), Dunger et al.
patent: 5470828 (1995-11-01), Ballard et al.
patent: 5534617 (1996-07-01), Cunningham et al.
patent: 5569648 (1996-10-01), Lewis et al.
patent: 5593844 (1997-01-01), Carlsson et al.
patent: 5597797 (1997-01-01), Clark
patent: 5622932 (1997-04-01), DiMarchi et al.
patent: 5652214 (1997-07-01), Lewis et al.
patent: 5703045 (1997-12-01), Lewis et al.
patent: 5714460 (1998-02-01), Gluckman et al.
patent: 5776897 (1998-07-01), Lewis et al.
Humbel E.R. Insulin-like growth factors I and II. European J. Biochem. 190:445-462 (1990).
Rudinger, J. "Characteristics of the amino acids as components of a peptide hormone sequence", in, Peptide Hormones, University Park Press, Jun. 1976.
Alberts et al., Molecular Biology of the Cell, 1994, Garland Publishing, Inc., New York, NY.
Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10.
Brandt et al. Role of natriutetic peptide clearance receptor in in vivo control of C-type natriuretic peptide. Am. J. Physiol., (Jul. 1995) 269 (1 Pt 2) H326-31.
Baxter et al. Structural determinants for binary and ternary complex formation between insulin-like growth factor-I (IGF-I) and IGF binding protein-3. J. Biol. Chem., (Jan. 5, 1992) (1) 60-5.
Cascieri et al. Analysis of the interaction of IGF-I analogs with the IGF-I receptor and IGF binding proteins. Adv Exp Med Biol 1993;343-33-40.
Clemmons et al. Competition for binding to insulin-like growth factor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs. Endocrinology Aug. 1992;131(2):890-895.
Heding et al. Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor-binding protein-3. J Biol Chem Jun. 14 1996;271(24):13948-13952.
Maack et al. Physiological role of silent receptors of atrial natriuretic factor. Science, Oct. 30, 1987, vol. 238, pp. 675-678.
Bach and Rechler, "Insulin-like Growth Factor Binding Proteins" Diabetes Reviews 3:38-61 (1995).
Ballard et al., "Does IGF-I Ever Act Through the Insulin Receptors" The Insulin-like Growth Factors and Their Regulatory Proteins, Baxter, eds., Amsterdam: Elsevier pp. 131-138 (1994).
Bar et al., "Tissue localization of perfused endothelial cell IGF binding protein is markedly altered by association with IGF-I" Endocrinology 127:3243-3245 (1990).
Bass et al., "Hormone Phage: An Enrichment Method for Variant Proteins with Altered Binding Properties" Proteins: Structure, Function, and Genetics 8(4):309-314 (1990).
Baxter, "Physiological Roles of IGF Binding Proteins" Modern Concepts of Insulin-like Growth Factors, Spencer, eds., Elsevier, New York pp. 371-380 (1991).
Baxter, "The somatomedins: insulin-like growth factors" Advances in Clinical Chemistry 25:49-115 (1986).
Baxter & Martin, "Binding Proteins for Insulin-Like Growth Factors in Adult Rat Serum. Comparison With Other Human and Rat Binding Proteins" Biochem. & Biophys. Res. Comm. 147(1):408-415 (1987).
Baxter, Robert C., "The Insulin-Like Growth Factors and Their Binding Proteins" Comp. Biochem. Physiol. 91B(2):229-235 (1988).
Bayne et al., "The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor" Journal of Biological Chemistry 264a:11004-11008 (1988).
Bayne et al., "The roles of tyrosines 24, 31, and 60 in the high affinity binding of insulin-like growth factor-I to the type I insulin-like growth factor receptor"Journal of Biological Chemistry 265:15648-15652 (1990).
Bayne et al., "Structural analogs of human insulin-like growth factor I with reduced affinity for serum binding proteins and the type 2 insulin-like growth factor receptor" Journal of Biological Chemistry 263:6233-6239 (1988).
Binkert et al., "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)" EMBO Journal 8:2497-2502 (1989).
Binoux, M., "Donnees recentes sur les somatomedines" Annales d'Endocrinologie 41:157-191 (1980) English abstract only.
Bondy, C., "Clinical uses of insulin-like growth factor I" Annals of Internal Medicine 120:593-601 (1994).
Bowers, C. Y., "GH Releasing Peptides--Structure and Kinetics" J. Pediatr. Endocrinology 6(1):21-31 (1993).
Brewer et al., "Cloning, Characterization, and Expression of a Human Insulin-Like Growth Factor Binding Protein" Biochem. & Biophys. Res. Comm. 152(3):1289-1297 (1988).
Brinkman et al., "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)" The EMBO J. 7:2417-2423 (1988).
Carlsson et al., "Growth Hormone and Growth in Diabetic Rats: Effects of Insulin and Insulin-Like Growth Factor-I Infusions" J. Endocrinol. 122:661-670 (1989).
Cascieri et al., "Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor" Biochemistry 27:3229-3233 (1988).
Cascieri et al., "Structural analogs of human insulin-like growth factor (IGF) I with altered affinity for type 2 IGF receptors" Journal of Biological Chemistry 264:2199-2202 (1989).
Charlton et al., "Growth hormone-deficient dwarfism in the rat: a new mutation" J. of Endocrinology 119:51-58 (1988).
Cheetham et al., "The Effects of Recombinant Human Insulin-like Growth Factor I on Growth Hormone Secretion in Adolescents With Insulin Dependent Diabetes Mellitus" Clin. Endocrinol. 40:515-522 (1994).
Cheetham et al., "The Effects of Recombinant Insulin-like Growth Factor I Administration on Growth Hormone Levels and Insulin Requirements in Adolescents With Type 1 (Insulin-dependent) Diabetes Mellitus" Diabetologia 36:678-681 (1993).
Chen et al., "Recombinant human IGF-I infusion results in transient improvement in nitrogen balance: evidence for IGF-I autoregulation" US Endocrine Meeting (Abstract 1596) pp. 449 (1993).
Clark et al., "Growth-Responses to Patterned GH Delivery" Endocrine 3:717-723 (1995).
Clark et al., "Insulin-Like Growth Factor and Growth Hormone (GH) Have Distinct and Over-Lapping Effects in GH-Deficient Rats" Endocrine 3:297-304 (1995).
Clemmons and Van Wyk, "Somatomedin: physiological control and effects on cell proliferation" Handbook Exp. Pharmacol. 57:161-208 (1981).
Clemmons et al., "Discrete Alterations of the Insulin-like Growth Factor I Molecule Which Alter Its Affinity for Insulin-like Growth Factor-binding Proteins Result in Changes in Bioactivity" Journal of Biological Chemistry 265(21):12210-12216 (1990).
Cwirla et al., "Peptides on phage: a vast library of peptides for identifying ligands" Proc. Natl. Acad. Sci. USA 87(16):6378-6382 (1990).
Devlin et al., "Random peptide libraries: a source of specific protein binding molecules" Science 249:404-406 (1990).
Duerr et al., "Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure" J. Clin. Invest. 95:619-627 (1995).
Elahi et al., "Hemodynamic and metabolic responses to human insulin-like growth factor I (IGF-I) in men" Modrn Concepts of Insulin-Like Growth Factors, Spencer, EM, ed., New York:E

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Insulin-like growth factor agonist molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insulin-like growth factor agonist molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insulin-like growth factor agonist molecules will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1074354

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.