N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo

Details N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo

1997-10-31

2000-01-04

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544326, 544330, 546208, 5462764, 5462791, 548530, 548540, C07D20734, C07D20742, C07D40106, C07D40510, C07D40906

Patent

active

060111550

ABSTRACT:
N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

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