Nucleic acid ligand complexes

Details Nucleic acid ligand complexes Nucleic acid ligand complexes

1995-05-04

2000-01-04

Zitomer, Stephanie

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 424450, 424 121, 424 173, 536 221, 536 231, 536 243, 536 2431, 935 77, C07H 2104, C07H 2102, C12Q 168, A61K 3170

Patent

active

060110201

ABSTRACT:
This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound.

REFERENCES:
patent: 4861597 (1989-08-01), Kida et al.
patent: 4904582 (1990-02-01), Tullis
patent: 5142047 (1992-08-01), Summerton et al.
patent: 5149794 (1992-09-01), Yatvin et al.
patent: 5227170 (1993-07-01), Sullivan
patent: 5245022 (1993-09-01), Weis et al.
patent: 5270163 (1993-12-01), Gold et al.
patent: 5279833 (1994-01-01), Rose
patent: 5459015 (1995-10-01), Janjic et al.
patent: 5472841 (1995-12-01), Jayasena et al.
patent: 5475096 (1995-12-01), Gold et al.
patent: 5476766 (1995-12-01), Gold et al.
patent: 5496938 (1996-03-01), Gold et al.
patent: 5503978 (1996-04-01), Schneider et al.
patent: 5527894 (1996-06-01), Gold et al.
patent: 5543293 (1996-08-01), Gold et al.
patent: 5567588 (1996-10-01), Gold et al.
patent: 5580737 (1996-12-01), Polisky et al.
Agrawal, et al (1995) Biochem. Pharm. 50:571-576.
Jaschke, et al (1994) Nuc. Acids Res. 22:4810-4817.
Jones, et al (1994) Bioconjugate Chem. 5:390-399.
Kabanov, et al (1990) FEBS Lets. 259:327-33.
Lasic, et al (1995) Science 267:1275-1276.
Laukkanen, et al (1994) Biochem. 33:11664-11670.
Letsinger, et al (1989) Proc. Natl. Acad. Sci. USA 86:6554-6556.
MacKellar, et al (1992) Nuc. Acids Res. 20:3411-3417.
Marcus-Sekura, et al (1987) Nuc. Acids Res. 15:5749-5763.
Oberhauser, et al (1992) Nuc. Acids Res. 20:533-538.
Saison-Behmoaras, et al (1991) EMBO J. 10:1111-1118.
Senior, et al (1991) Biochim. et Biophys. 1062:77-82.
Shea, et al (1990) Nucl. Acids Res. 18:3777-3783.
van der Krol, et al (1988) Biotechniques 6:958-974.
Wang, et al (1995) Proc. Natl. Acad. Sci. USA 92:3318-3322.
Zhang, et al (1995) Biochem. Pharm. 49:929-939.
Zhang, et al (1995) Biochem. Pharm. 50:545-556.
Joyce (1989) Gene 82:83.
Joyce & Inoue (1989) Nucleic Acids Research 17:711.
Ellington & Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 84.
Kinzler & Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn & Spiegelman (1969) PNAS USA 63:805.
Levisohn & Spiegelman (1968) PNAS USA 60:866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant & Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant & Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson & Joyce (1990) Nature 344:467.
Thiesen & Bach (1990) Nucleic Acids Research 18:3203.
Jablonski et al., Nuc. Acids Res. 14(15):6115-6128 (1986).

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