Use of growth factors to treat drug-inducted neuropathy

Details Use of growth factors to treat drug-inducted neuropathy Use of growth factors to treat drug-inducted neuropathy

1996-12-17

2000-01-04

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530350, 530399, A61K 3818

Patent

active

06011004&

ABSTRACT:
This invention relates to the use of neuronotrophic factors, such as nerve growth factor (NGF), ciliary derived neuronotrophic factor (CNTF), brain derived neuronotrophic factor (BDNF), neuronotrophin-3 (NT-3), fibroblast growth factor (FGF), epidermal growth factor (EGF), transforming growth factor .alpha. (TFG-.alpha.), transforming growth factor .beta. (TGF-.beta.) and others to prevent drug-induced neuropathy.

REFERENCES:
Mollman J.E. `Cisplatin Neurtoxicity`, The New England Journal of Medicine. Jan. 11, 1990; pp. 126-127, 1990.
Peterson et al. `Never growth Factor Attenuates Nerutoxic Effects of Taxol on Spinal Cord-Ganglion Explants from Fetal Mice`, Science, Vol. 217. pp. 377-379, 1987.
Jacowski et al. `Neural injury repair: hope for the future as barrier to effective CNS regeneration become clearer.` British Journal of Neurosergery. vol. 9, pp. 303-317, 1995.
Database Caplus on STN. No. 10996:540531. Riaz et al. `Neurotrophic factors in pherperal neuropathes: pharmacological strategies` Prog. Neurobiol. vol. 42, No. 1, pp. 125-143 (Abstract), 1996.

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