Expression of heterologous polypeptides in halobacteria

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 691, 4352523, 4353201, 435471, 435476, C12N 121, C12N 1574, C12P 2100, C12P 2102

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060108851

ABSTRACT:
This invention relates to the preparation and use of expression systems capable of producing heterologous polypeptides in halobacterial hosts.

REFERENCES:
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Ni et al., "An Efficient System for the Synthesis of bacteriorhodopsin in Halobacterium halobium," Gene, 90:169-172 (1990).
Birge, "Photophysics and Molecular Electronic Applications of the Rhodopsins," Annu. Rev. Phys. Chem., 41:683-733 (1990).
Betlach et al., "Characterization of a halobacterial Gene Affecting Bacterioopsin Gene Expression," Nucleic Acids Research, 12:7949-7959 (1984).
Dunn et al., "The Bacteriorhodopsin Gene," PNAS USA, 78:6744-6748 (1981).
Dunn et al., "Structure-Function Studies on Bacteriorhdopsin," J. Biol. Chem., 262(19):9246-9254 (1987).
Krebs et al., "Expression of the Bacterioopsin gene in Halobacterium halobium Using a Multicopy Plasmid," PNAS USA, 88:859-863 (1991).
Derwent Abstract of Japanese Patent 3151883 (Jun. 28, 1991).
Derwent Abstract of Japanese Patent 59036700 (Feb. 28, 1984).
The Patent Office Japanese Government "Patent Abstracts of Japan," 8(126):228 (1984).

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