Chemistry: analytical and immunological testing – Automated chemical analysis – Utilizing a centrifuge or compartmented rotor
Patent
1994-10-18
2000-09-19
Alexander, Lyle A.
Chemistry: analytical and immunological testing
Automated chemical analysis
Utilizing a centrifuge or compartmented rotor
436 94, 436165, G01N 3502
Patent
active
06121048&
ABSTRACT:
An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.
REFERENCES:
patent: 3281860 (1966-10-01), Adams et al.
patent: 3710933 (1973-01-01), Fulwlyer et al.
patent: 4121222 (1978-10-01), Diebold et al.
patent: 4373071 (1983-02-01), Itakura
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4500707 (1985-02-01), Caruthers et al.
patent: 4728502 (1988-03-01), Hamill
patent: 4731325 (1988-03-01), Palva et al.
patent: 4780504 (1988-10-01), Buendia et al.
patent: 4812512 (1989-03-01), Buendia et al.
patent: 4877745 (1989-10-01), Hayes et al.
patent: 4992383 (1991-02-01), Farnsworth
patent: 5021550 (1991-06-01), Zeiger
patent: 5047524 (1991-09-01), Andrus et al.
patent: 5141813 (1992-08-01), Nelson
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5153319 (1992-10-01), Caruthers et al.
patent: 5256549 (1993-10-01), Urdea
patent: 5288514 (1994-02-01), Ellman
patent: 5358691 (1994-10-01), Clark et al.
patent: 5677195 (1997-10-01), Winkler et al.
patent: 5698393 (1997-12-01), Macioszek et al.
patent: 5807522 (1998-09-01), Brown et al.
H. Mario Geysen et al., J. Immunological Methods 102 (1987) 259-274, Strategies for epitope analysis using peptide synthesis.
R.B. Merrifield, J. Am. Chem. Soc., 85 Jul. 20, 1963 2149-2154, Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide.
Ohlmeyer, H.J., et al., Proc. Natl. Acad. Sci. USA, vol. 90, 10922-10926 (1993), "Complex Synthetic Chemical Libraries Indexed With Molecular Tags. "
Tuerk, C., et al., Science, vol. 249, 505-510 (1990), "Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase."
Needels, M.C., et al., Proc. Natl. Acad. Sci. USA, vol. 90, 10700-10704 (1993), "Generation and Screening of an Oligonucleotide-Encoded Synthetic Peptide Library."
Lam, K.S., et al., Nature, vol. 354, 82-84 (1991), "A New Type of Synthetic Peptide Library for Identifying Ligand-Binding Activity."
Houghten, R.A., et al., Nature, vol. 354, 8486 (1991), "Generation and Use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Discovery."
Cwirla, S.E., et al., Proc. Natl. Acad. Sci. USA, vol. 87, 6378-6382 (1990), "Peptides on Phage: A Vast Library of Peptides for Identifying Ligands."
Fodor, S.P.A., et al., Science, vol. 251, 767-773 (1991), "Light-Directed, Spatially Addressable Parallel Chemical Synthesis."
Buchko Christopher J.
Modlin Douglas N.
Zaffaroni Alejandro C.
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