Antisense modulation of SHP-1 expression

Details Antisense modulation of SHP-1 expression Antisense modulation of SHP-1 expression

1999-07-21

2000-09-19

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585

Patent

active

061210471

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of SHP-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SHP-1. Methods of using these compounds for modulation of SHP-1 expression and for treatment of diseases associated with expression of SHP-1 are provided.

REFERENCES:
patent: 5659012 (1997-08-01), Klingmuller et al.
Branch, TIBS 23, pp. 45-50, Feb. 1998.
Flanagan et al., Nature Biotech. 17:48-52, Jan. 1999.
Crooke, from Antisense Research & Application, pp. 1-50, 1998.
Uhlmann, Chem. Rev. vol. 90 No. 4, pp. 543-584, Jun. 1990.
Martin, Helvetica Chimica Acta vol. 78, pp. 486-504, 1995.
James, Antiviral Chem & Chemotherapy 2(4), pp. 191-214, 1991.
Milner, Nature Biotech. vol. 15, pp. 537-541, Jun. 1997.
Bone et al., SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates, J. Biol. Chem., 1997, 272:14470-14476.
Gaits et al., G-protein bg subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid, J. Biol. Chem., 1996, 271:20151-20155.
Huber et al., The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells, J. Biol. Chem., 1999, 274:335-344.
Kasugai et al., A variant of the HL-60 cell line expressing a high level of PTP1C exhibits increased susceptibility to differentiation by phorbol 12-myristate 13-acetate, Cancer Lett. (Shannon, Irel.), 1997, 120:223-227.
Kimura et al., Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor, J. Immunol., 1997, 159:4426-4434.
Mizuno et al., Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells, J. Exp. Med., 1996, 184:457-463.
Neel, Structure and function of SH2-domain containing tyrosine phosphatases, Semin. Cell. Biol., 1993, 4:419-432.
Olcese et al., Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases, J. Immunol., 1996, 156:4531-4534.
Pani et al., Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase, J. Exp. Med., 1996, 184:839-852.
Pei et al., Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1, Proc. Natl. Acad. Sci. U. S. A., 1996, 93:1141-1145.
Plutzky et al., Isolation of a src homology 2-containing tyrosine phosphatase, Proc. Natl. Acad. Sci. U. S .A., 1992, 89:1123-1127.
Shen et al., A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases [published erratum appears in Nature 1991 Oct. 31;353(6347):868], Nature, 1991, 352:736-739.
Shultz et al., Severe defects in immunity and hematopoiesis caused by SHP-1 protein- tyrosine-phosphatase deficiency, Trends Biotechnol., 1997, 15:302-307.
Siminovitch et al., Regulation of B cell signal transduction by SH2-containing protein- tyrosine phosphatases, Semin. Immunol., 1998, 10:329-347.
Srikant et al., Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells, Endocrinology, 1996, 137:3461-3468.
Su et al., Positive effect of overexpressed protein-tyrosine phosphatase PTP1C on mitogen-activated signaling in 293 cells, J. Biol. Chem., 1996, 271:10385-10390.
Uchida et al., Phorbol ester stimulates the activity of a protein tyrosine phosphatase containing SH2 domains (PTP1C) in HL-60 leukemia cells by increasing gene expression, J. Biol. Chem., 1993, 268:11845-11850.
Yi et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification, Blood, 1991, 78:2222-2228.
Yi et al., Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13, Mol. Cell. Biol., 1992, 12:836-846.
Zhang, Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis, Crit. Rev. Biochem. Mol. Biol., 1998, 33:1-52.

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