MurE

Details MurE MurE

1997-10-10

2000-09-19

Sisson, Bradley

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

4352523, 43525411, 4353201, 435325, 435410, 536 221, 536 231, 536 232, 536 237, C12N 900, C12N 120, C12N 1500, C07H 2104

Patent

active

061210285

ABSTRACT:
The invention provides MurE polypeptides and DNA (RNA) encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5712108 (1998-01-01), Peery et al.
patent: 5821096 (1998-10-01), Peery et al.
Daniel, et al., GenBank Submission, Accession No.P46343, "(EC 6.3.2.13)(UDP-N-acetylmuramyl-Tripeptide."
Michaud, et al., "Over-production, purification and properties of the uridine-disulfate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli." Eur. J. Biochem., vol. 194, pp. 853-861, (1990).
Itaya, et al. "A new micromethod for the colorimetric determination of inorganic phosphate." Clinica Chimica Acta, vol. 14, pp. 361-366, (1966).
Partial European Search Report, completed Aug. 27, 1999.
Daniel, et al., "DNA Sequence of the murE-murD region of Bacillus subtilis168", Journal of General Microbiology, vol. 139, 1 pp. 361-380, XP-002089957 (Jan. 1, 1993).
Van Assche, et al., "Synthesis and antibacterial evaluation of phosphonic acid analogues of diaminopimelic acid", European Journal of Medicinal Chemistry, vol. 26, pp. 505-515, XP002113546 (1991).

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