Process and intermediates for preparing cephalosporin antibiotic

Details Process and intermediates for preparing cephalosporin antibiotic Process and intermediates for preparing cephalosporin antibiotic

1976-03-25

1979-04-10

Shaver, Paul F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544 29, 544 26, 544 27, 544 28, 544 30, 544 21, 2603067C, 424246, 560 39, C07F 718

Patent

active

041488172

ABSTRACT:
The silylated and enamine protected D-3- or 4-hydroxyphenylglycine as the sodium salt of the formula ##STR1## wherein A is methyl or ethyl, are crystalline intermediates useful in a new process for the acylation of heterocyclic-thiomethyl-substituted cephalosporin nuclei, e.g. 7-amino-3-(5-methyl-1,3,4-thiadiazole-2-ylthiomethyl)-3-cephem-4-carboxyli c acid and 7-amino-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic acid.

REFERENCES:
patent: 3651116 (1972-03-01), Lincoln et al.
patent: 3770788 (1973-11-01), Bundy
patent: 3787449 (1974-01-01), Collins et al.
patent: 3892792 (1975-07-01), Yankee
patent: 4003894 (1977-01-01), Verweij et al.
patent: 4035361 (1977-07-01), Wheeler
patent: 4045438 (1977-08-01), Haviv et al.
patent: 4075219 (1978-02-01), McShane

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