Antidiuretically effective polypeptide and a process for prepari

Details Antidiuretically effective polypeptide and a process for prepari Antidiuretically effective polypeptide and a process for prepari

1977-11-08

1979-04-10

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, C07G 700, A61K 37100

Patent

active

041487877

ABSTRACT:
Antidiuretically effective vasopressin derivates of the formula ##STR1## in which Mep is a 2-mercaptopropionyl residue (--S--CH.sub.2 CH.sub.2 CO--), and A and B are glutamine (Gln) or asparagine (Asn) and A is Gln only when B is Gln and D-arginine is in position 8.
A method for preparing the derivatives comprises the steps of gradually producing the amino acid sequence

REFERENCES:
patent: 3418307 (1968-12-01), Borssonnas et al.
patent: 3454549 (1969-07-01), Borssonnas et al.
patent: 3497491 (1970-02-01), Zaoral et al.

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