Ternary radiopharmaceutical complexes

Details Ternary radiopharmaceutical complexes Ternary radiopharmaceutical complexes

1998-01-26

2000-01-04

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 165, 534 10, 534 14, 530 17, 514 9, 514 11, A61K 5100, A61M 3614

Patent

active

060106794

ABSTRACT:
This invention provides novel radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders, infectious disease and cancer. The radiopharmaceuticals are comprised of phosphine or arsine ligated technetium-99m labeled hydrazino or diazino modified biologically active molecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. This invention also provides methods for using the radiopharmaceuticals and kits comprising radiopharmaceutical precursors. The radiopharmaceuticals of this invention have the structure:

REFERENCES:
patent: 5066789 (1991-11-01), Srinivasan et al.
patent: 5300278 (1994-04-01), Pasqualini et al.
patent: 5350837 (1994-09-01), Bridger et al.
patent: 5744120 (1998-04-01), Edwards et al.

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