Humoral hypercalcemic factor antagonists

Details Humoral hypercalcemic factor antagonists Humoral hypercalcemic factor antagonists

1990-07-26

1992-09-22

Chan, Y. Christina

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530307, C07K 754, C07K 736, A61K 3702

Patent

active

051497794

ABSTRACT:
Peptide analogues of human humoral hypercalcemic factor (hHCF) that contain a lactam bridge act as inhibitors of the naturally occurring peptide. A lactam bridge between Lys and Asp situated five residues (inclusive) apart confers rigidity to that region of the peptide, and enhances the helical nature and metabolic stability of the peptide analogue.

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