Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1986-02-26

1987-11-10

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Lymphokine

514396, A61K 3178, A61K 31415

Patent

active

047056835

ABSTRACT:
Pharmaceutical compositions comprising mixtures of a histamine H.sub.2 -receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of a histamine H.sub.2 -receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers. In a modification in the mixtures the sodium polyacrylate may be replaced wholly or in part by potassium or ammonium polyacrylate.

REFERENCES:
patent: 4140760 (1979-02-01), Withington
patent: 4273761 (1981-01-01), Matsuda et al.
A. Watson, British Society of Gastroenterology, 25, pp. A553-A554, (1985).
Bennett et al., The British Society of Gastroenterology, 25, p. A556, (1984).

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