Substituted thiazoles as immunoregulants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544298, 544300, 544405, 544180, 544215, 544297, 514252, 514256, 514307, 514314, 514333, 514338, 514339, 514337, 514362, 514363, 514367, 514365, 546280, 546141, 546142, 546143, 546144, 546145, 546148, 546153, 546155, 546157, 546159, 546256, 548202, 548203, 548204, 548205, 548186, 548187, 548184, 548181, 548134, 548135, 548136, 548138, A61K 3138, C07D40904, C07D40906, C07D21704, C07D27722

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active

047466693

ABSTRACT:
Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with diphosphoryl pentasulfide. The thiazole derivatives are found to be effective immunoregulants.

REFERENCES:
patent: 3821384 (1974-06-01), Ariyan et al.
patent: 4260765 (1981-04-01), Harrison et al.
patent: 4363813 (1982-12-01), Kawasaki et al.
patent: 4385059 (1983-05-01), Franklin
Goodman et al., The Pharmacological Basis of Therapeutics, p. 28.

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