Ergoline compounds useful as antiparkinson agents

Details Ergoline compounds useful as antiparkinson agents Ergoline compounds useful as antiparkinson agents

1986-06-16

1988-05-24

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, 546 68, A61K 3148, C07D45704

Patent

active

047466669

ABSTRACT:
Ergoline derivatives of the formula I ##STR1## wherein R.sub.1 =H,CH.sub.3 ; R.sub.2 =H, halogen, CH.sub.3, CN, C.sub.1 -C.sub.4 alkylthio or phenylthio; R.sub.3 =C.sub.1 -C.sub.4 hydrocarbon; R.sub.4 =H, OCH.sub.3 ; R.sub.5 =H and R.sub.6 =--CH.dbd.CH--CONHR.sub.7 or R.sub.5 and R.sub.6 =.dbd.CH--CONHR.sub.7 ; R.sub.7 =2-thiazolyl, 3-pyridazinyl, 1,3,4-thiadiazol-2-yl or 4-pyrimidinyl group optionally substituted, and pharmaceutically acceptable salts thereof, display activity on the Central Nervous System and are useful as antiprolactinic agents. Their preparation and pharmaceutical compositions containing them are also described.

REFERENCES:
patent: 3647655 (1972-03-01), Bernardi et al.
patent: 4180581 (1979-12-01), Stadler
patent: 4500712 (1985-02-01), Bernardi et al.
patent: 4690929 (1987-09-01), Bernardi et al.
Bernardi et al, CA 74-42536n.
The Journal of the American Chemical Society, vol. 83, 1961, W. S. Wadsworth et al., "The Utility of Phosphonate Carbanions in Olefin . . . ", pp. 1733-1738.

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