Treatment of arthritis with 3,5-dichloromethotrexate

Details Treatment of arthritis with 3,5-dichloromethotrexate Treatment of arthritis with 3,5-dichloromethotrexate

1987-02-20

1988-05-24

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61U 31505

Patent

active

047466626

ABSTRACT:
Joint destruction associated with arthritic disease in warm blooded animals is treated with unexpected safety using 3,5-dichloromethotrexate. The therapeutic index therefor is unexpectedly enhanced through combination therapy using a post administration of leucovorin.

REFERENCES:
patent: 4426384 (1984-01-01), Wyburn-Mason
See-Lasley et al., Manual of Oncology Therapeutics (1981), pp. 228-229.
Chem. Abst., 99 (1983), 115, 669m.

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