Transgenic animal model system for human cutaneous melanoma

Details Transgenic animal model system for human cutaneous melanoma Transgenic animal model system for human cutaneous melanoma

1993-01-29

1996-08-27

Stone, Jacqueline M.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 536 231, 536 2372, 536 241, 424 92, C12N 1500, A01K 6700

Patent

active

055503160

ABSTRACT:
The present invention relates to transgenic animal model systems for human cutaneous melanoma. It is based, at least in part, on the discovery that, in susceptible transgenic mice, accelerated formation of melanoma tumors occurred near the wound borders of skin grafts carrying the Tyr-SV40E transgene, indicating that factors present during wound healing facilitate the formation of cutaneous melanoma in susceptible tissue.

REFERENCES:
B Mintz et al (1993) Proc Natl. Acad. Sci USA 90:8817-8821.
R Halaban (1991) Cancer Metastasis Rev 10(2):129-140.
M Bradl et al (1991) Proc Natl Acad Sci, USA 88:164-168.
K N Broadley et al (1989) Laboratory Investigation 61:571-575.
Hesketh (1995) The Oncogene Facts Book, pp. 32-42.
Strojek et al (1988) Genetic Engineering: Principles and methods, 10:238.
Loudon et al (1993) Clin Exp Pharmacol Physiol 20: 283-288.

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