Solid phase peptide synthesizer

Details Solid phase peptide synthesizer Solid phase peptide synthesizer

1986-02-06

1988-05-24

Lacey, David L.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Automatic analytical monitor and control of industrial process

422 81, 422111, 422113, 422116, 422135, 422189, 422228, 422234, 435289, 436 55, 436 89, 436161, 525 5411, 935 87, 935 88, C07K 108, C12M 100, G05B 1700

Patent

active

047464909

ABSTRACT:
An apparatus for peptide synthesis in which a plurality of supply valves are arranged in series to define a line for supplying successive reagents to a reaction vessel in which a peptide is to be synthesized. A corresponding plurality of containers contain respective reagents and each, by actuation of its corresponding valve, is connectable through downstream ones of the series of valves to supply its respective reagent to the reaction vessel. For cleaning or reacting with peptide starting material therein further valving permits draining of the reaction vessel to waste and, between applications of successive reagents to the reaction vessel, cleaning of the line of valves by flushing with a cleaning reagent sent from the upstream end of the series of valves through the line to waste. In modified embodiments, the plurality of reagent containers and series line of valves supplies reagents to multiple reaction vessel chambers in such a way that the multiple chamber may simultaneously be occupied by the same reagent in one peptide synthesis step and by several differing reagents, delivered thereto in sequence, in a differing peptide synthesis step, to enable simultaneous production of similar but different peptide analogs.

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Derwent Abstracts Numbered: 22142U-BJ;77679R-BJ;03421R;70094W/42;67479W/41;61682V/35;53709T-B;338835-B .

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