Gelatinase A inhibitor, and analytical reagent thereof for the d

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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530324, 530354, 530355, 530828, 436 64, 436 86, 436 87, C07K 1700, A61K 3800, G01N 3300

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active

055502164

ABSTRACT:
The present invention relates to a gelatinase A inhibitor comprising as an active ingredient a peptide analogue consisting of an active minimum unit of gelatinase A inhibition obtained from APP (.beta.-amyloid precursor) or a peptide analogue comprising it. Gelatinase A can be qualified and quantified using any of the gelatinase A inhibitors according to the present invention.

REFERENCES:
patent: 5436153 (1995-07-01), Sprecher et al.
patent: 5441931 (1995-08-01), Sprecher et al.
R. Tanzi et al., "Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease," Nature, vol. 331, No. 6156, pp. 528-530, Feb. 1988.
H. Kido et al., "Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor," Biochemical and Biophysical Research Communications, vol. 167, No. 2, pp. 716-721 Mar., 16, 1990.
K. Miyazaki et al., "Processing enzyme of Alzheimer amyloid protein precursor and its inhibitor," Chemical Abstracts, vol. 120, No. 13, Abstract No. 156752, p. 424, col. 1, Mar. 1994.
Miyazaki et al, Nature, vol. 362, pp. 839-841, 29 Apr. 1993.
Liotta, Cancer Research, vol. 46, pp. 1-7, Jan. 1986.
Yamagata et al, Biochemical and Biophysical Research Communications, vol. 151, No. 1, pp. 158-162, Feb. 1988.
Stetler-Stevenson et al, The Journal of Biological Chemistry, vol. 264, No. 29, pp. 17374-17378, Oct. 1989.
Goldberg et al, Proc. Natl. Acad. Sci. USA, vol. 86, pp. 8207-8211, Nov. 1989.
Yasumitsu et al, J. Biochem, vol. 111, pp. 74-80, 1992.
Kato et al, The Journal of Biological Chemistry, vol. 267, No. 16, pp. 11424-11430, Jun. 5, 1992.
Miyazaki et al, The Journal of Biological Chemistry, vol. 268, No. 19, pp. 14387-14393, Jul. 1993.
Walsh et al, Nature, vol. 367, pp. 27-28, 6 Jan. 1994.
K. Miyazaki et al. "Activation of TIMP-2/Progelatinase A Complex by Stromelysin." Biochemical and Biophysical Research Communications. vol 185, No. 3, 1992. Jun. 30, 1992.
Hansjorg Kolkenbrock et al. "The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor." Eur. J. Biochem. 198, 775-781 (1991).
K. Miyazaki et al. "Gelatinase A and APP." Nature. vol. 368. 21 Apr. 1994.

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