N,O-sulphated heparosans and pharmaceutical compositions contain

Details N,O-sulphated heparosans and pharmaceutical compositions contain N,O-sulphated heparosans and pharmaceutical compositions contain

1995-02-15

1996-08-27

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 53, 514 54, 536 21, 536 53, 536 54, 536 55, 536 551, 536 552, A61K 31725

Patent

active

055501168

ABSTRACT:
The invention relates to N,O-sulphated heparosans consisting of chains or of a mixture of chains of molecular mass between 1500 and 15,000 Da, characterized by a repeated disaccharide structure of formula I: ##STR1## in which: E represents an acetyl group in 0 to 80% of the disaccharide units of the said N,O-sulphated heparosan, and a sulphate group and possibly a hydrogen atom in the remaining disaccharide units,

REFERENCES:
patent: 3211616 (1965-10-01), Yosizawa
patent: 4727063 (1988-02-01), Naggi et al.
patent: 4816446 (1989-03-01), Feller et al.
patent: 4990502 (1991-02-01), Lormeau et al.
patent: 5008253 (1991-04-01), Casu et al.
patent: 5013724 (1991-05-01), Petitou et al.
patent: 5071969 (1991-12-01), Van Boeckel et al.
Gupta et al; FEMS Microbiol. Lett. 16:13-17 (1983).
Atha et al; Biochem. 26:6454-61 (1987).
Sugahara et al; Biochem. Biophys. Res. Commun. 162(1):189-197 (1989).
Bashkin et al; Biochem. 28:1737-43 (1989).
Platt et al; Dev. Biol. 139:338-48 (1990).
Hurley et al; Chemical Abstracts 114:239930n (1991).
Lindahl et al; J. Biol. Chem. 248(20):7234-41 (1973).
Nagasawa et al; J. Biochem. 81:989-993 (1977).
Linker; Biochem. J. 183:711-720 (1979).
Riesenfeld et al; J. Biol. Chem. 255(3):922-8 (1980).
Sj oberg et al; Biochem. J. 191:103-110 (1980).
Vann et al; Eur. J. Biochem. 116:359-364 (1981).
The Merck Index 10th Ed. pp. 672-673 #4543 (1983).
Sanderson et al; Biochem. J. 211:677-682 (1983).
J. L. Navia et al., "Assay of N-Acetylheparosan Deacetylase with a Capsular Polysaccharide from Escherichia coli K5 as Substrate", Analytical Biochemistry, vol. 135, 1983, pp. 134-140.

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