Substituted phenylthioamidines

Details Substituted phenylthioamidines Substituted phenylthioamidines

1975-08-11

1976-11-30

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26050114, C07C12300

Patent

active

039949761

ABSTRACT:
Substituted phenylthioamidine compounds such as 2-(4-chlorophenylthio)acetamidine; 2-(4-chlorophenylthio)-acetamidoxime; and their pharmaceutically-acceptable salts are prepared by the reaction of a substituted phenylthioacetonitrile with hydroxylamine hydrochloride or with methanol followed by ammonium chloride. The compounds have antimicrobial activity and also inhibit ADP-induced aggregation of blood platelets.

REFERENCES:
patent: 3790679 (1974-02-01), Shea
Craver et al., J. Pharmacology & Experimental Therapeutics, vol. 99, pp. 353-361, (1950).

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