Process for preparing isoquinolines

Details Process for preparing isoquinolines Process for preparing isoquinolines

1992-01-15

1994-07-26

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21720

Patent

active

053328213

ABSTRACT:
A process for the preparation of isoquinolines of the formula ##STR1## wherein R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl, by reacting a solution of an enamine of the formula ##STR2## wherein R and R' are as described above, in a hydrocarbon with an anhydrous solution of p-toluenesulphonic acid in toluene or xylene at an elevated temperature.

REFERENCES:
patent: 3479358 (1969-11-01), Hausen et al.
patent: 4707485 (1987-11-01), Kaiser et al.
Barton, International Series of Monographs In Organic Chemistry, vol. 8, Part IIA Morphinans, pp. 10-32 (1966).
Sugimoto, et al., Studies on the Synthesis of Hydrogenated Quinolines and Isoquinolines as Anagesics, Chem. Pharm. Bull 6, 429 (1958).
Meyers, et al. An Asymmetric Synthesis of (+)-Morphinans in High Enantiomeric Purity, J. Org. Chem. 51, 872 (1986).
Reimann, et al., Selective Catalytic Hydrogenations and Hydrogenolyses, Arch. Pharm. 318, 685 (1985).
Grewe, et al., Annalen Der. Chemie, Preparation of Octahydro Isoquinoline Derivatives by Cyclization (1953).

Affiliated with

Also associated with

Rating

Process for preparing isoquinolines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing isoquinolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing isoquinolines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1053964