Process for the preparation of carbacyclic nucleosides, and inte

Details Process for the preparation of carbacyclic nucleosides, and inte Process for the preparation of carbacyclic nucleosides, and inte

1992-10-30

1994-07-26

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544254, 544264, 544265, 544266, 544271, 544272, 544276, 544277, 544280, 544311, 544312, 544313, 544314, 544317, 546 14, 546118, 549 15, 549228, 549363, 549214, 568838, C07D47318, C07D47302, C07D23947, C07D239553

Patent

active

053328140

ABSTRACT:
Process for the preparation of racemic compounds of the formula I ##STR1## or enantiomers thereof, in which B is the radical of a nucleic base from the series comprising purine, a purine analogue or a pyridine analogue, and R is H or a protective group R.sub.1, by reacting

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Aldrich 1990 Catalog, p. 316.
Lowe et al Journal of the Chemical Society Chemical Communications No. 23, 1983 pp. 1392-1394.
Biggadike et al Journal of the Chemical Society. Chemical Communications No. 14, 1987, pp. 1083-1084.
Bodenteich et al Nucleosides & Nucleotides, 6 (182) pp. 233-237 (1990).
Szenzo, Tetrahedron Letter, vol. 31, No. 10 pp. 1463-1466 (1990).
Biggadike J. Chem. Soc. Chem. Commun pp. 1083-1084 (1987).
Balzarini et al J. Med. Chem. vol. 32, pp. 1861-1965 (1989).
Beres et al J. Med. Chem. vol. 33, pp. 1353-1360 (1990).
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