Process for producing gangliosides

Details Process for producing gangliosides Process for producing gangliosides

1989-05-16

1990-04-17

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 53, 536 551, 536 553, 536124, 514 54, C07H 100, C07G 3700, C07G 1700, A01N 4304

Patent

active

049181700

ABSTRACT:
The present invention provides a novel process for producing gangliosides such as GM.sub.3 and GM.sub.4 and analogues thereof. This process has the excellent characteristics in that in introduction of ceramide into sialooligosaccharides, first an azidosphingosine derivative is introduced and then the azido portion is reduced to effect N-acylation. The present invention has a conspicuous effect in that the yield is markedly improved as compared with conventional processes.

REFERENCES:
Glyconjugate J. (1985), 2:5-9; Sugimoto, Mamoru and Ogawa, Tomoya; Synthesis of a Hematoside (G.sub.M3 -Ganglioside) and a Stereoisomer.
Carbohydrate Research, 163 (1987), 209-225, Numata, Masaaki; Sugimoto, Mamory; Kioke, Katsuya and Ogawa, Tomoya, Total Synthesis of Sialosylcerebroside, GM.sub.4.

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