Amino-1,3,5-triazines and their anhydrobase derivatives as agent

Details Amino-1,3,5-triazines and their anhydrobase derivatives as agent Amino-1,3,5-triazines and their anhydrobase derivatives as agent

1990-12-03

1994-07-26

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544194, 544196, 544197, 544200, 544208, 544209, 544211, 544198, A61K 3153, C07D25140, C07D25148

Patent

active

053327373

ABSTRACT:
This invention concerns novel compounds of the formula I: ##STR1## in which P is a group of formula II or a group of formula III; R.sup.1 is alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl; R.sup.2 is hydrogen, alkyl, amino or alkylamino; R.sup.3 and R.sup.4 are independently hydrogen, alkyl, phenyl or benzyl; R.sup.6 is alkyl amino or alkylamino; C and D are independently ethylene or trimethylene; Z is a direct bond between C and D, or an oxy, thio, carbonyl, methylene, ethylenedioxymethylene, ethylidene, or isopropylidene link, or Z is a group of the formula .dbd.N.R.sup.5 in which R.sup.5 is alkyl, phenyl or benzyl; R8 is hydrogen, cycloalkylalkyl, alkyl, alkenyl, alkynyl or phenylalkyl; or R8 is a alkylene or alkenylene linked to the nitrogen atom of the group Q.A.N--, either of which linking groups may optionally bear a alkyl, phenyl or phenylalkyl substituent and either of which linking groups thereby completes a ring including two adjacent carbon atoms of ring Q, any carbon atoms in A and the adjacent nitrogen atom of the group --A.N--; A is a direct bond to the the group --N(R8)-- or is alkylene; Q is a phenyl or pyridyl moiety; Y is a physiologically acceptable anion; and wherein any one or more of said phenyl, benzene or pyridyl moieties may optionally be unsubstituted or bear one or more selected substituents.
The invention also includes certain closely related anhydo-base derivatives which, like the compounds of formula I, possess beneficial effects on the cardiovascular system (and in particular beneficial effects modulated via the sino-atrial node). Also included are pharmaceutical compositions containing compounds of formula I (or a related anhydro-base) as active ingrdient, and processes for the manufacture of the various novel compounds.

REFERENCES:
patent: 3729468 (1973-04-01), Tani et al.
patent: 3759911 (1973-09-01), Irikura et al.
patent: 4312988 (1982-01-01), Jacobs, III et al.
Csuros et al, Acta Chemica Acad. Sci. Hungaucal 78(4) pp. 409-417, 1973.
English translation of entire article abstrated as Chemical Abstracts, vol. 86, No. 9, Abstr. No. 55393M, 1986.

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