Carboxamide derivatives of indoles and leucotriene antagonizing

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

548500, 548506, C01D20922, A61K 31405

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active

049180940

ABSTRACT:
This invention provides a series of novel heterocyclic amides of formula I in which the group >X-Y-Z< is selected from >C.dbd.CH--N<, >C.dbd.N--N<, >N--(CH.sub.2)--N<, >CH--CH.sub.2 --N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification.

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Krell, Robert D., "Pharmacologic Characterization of Isolated Rhesus Monkey Bronchial Smooth Muscle", The Journal of Pharmacology and Experimental Therapeutics, vol. 211, No. 2, pp. 436-443, (1979).
Marx, Jean L., "The Leukotrienes in Allergy and Inflammation", Science, vol. 215, Mar. 12, 1982, pp. 1380-1382.
Fleisch, Jerome H., Rinkema, Lynn E., Haisch, Klaus D., Swanson-Bean, Dorothy, Goodson, Theodore, Ho, Peter P. K., and Marshall, Winston S., "LY171883, 1<2-Hydroxy-3-Propyl-4-<4-(1H-Tetrazol-5-yl) Butoxy>Phenyl>Ethanone, and Orally Active Leukotriene D. Antagonist", The Journal of Pharmacology and Experimental Therapeutics, vol. 233, No. 1, pp. 148-157, (1985).
Denzlinger, C., Rapp, S., Hagmann, W. and Keppler, D., "Leukotrienes as Mediators in Tissue Trauma", Science, vol. 230, pp. 330-332 (1985).
Cook, J. A., Wise, W. C. and Halushka, P. V., "Protective Effect of a Selective Leukotriene Antagonist in Endotoxemia in the Rat", The Journal of Pharmacology and Experimental Therapeutics, vol. 235, No. 2, pp. 470-474, (1985).

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