Platelet membrane microparticles

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood

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424529, 435236, A61K 3514, C12N 704

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active

053325788

ABSTRACT:
A heat-treated, viral-inactivated platelet membrane microparticle product is provided. The microparticles may be prepared from outdated mammalian platelets. The microparticle product contains isolated platelet membrane fragments that are free of alloantigens and GP IIb/IIIa complexes further, the product may be used as a pharmaceutical preparation in transfusions.

REFERENCES:
patent: 4456590 (1984-06-01), Rubinstein
patent: 4540573 (1985-09-01), Neurath et al.
patent: 4731053 (1988-03-01), Hoffman
patent: 4753797 (1988-06-01), Garcez
patent: 4760131 (1988-07-01), Sundsmo et al.
patent: 4764463 (1988-08-01), Mason et al.
patent: 4871488 (1989-10-01), Mannino et al.
patent: 4994438 (1991-02-01), Rubinstein
patent: 5185160 (1993-02-01), Chao
George et al., Biol. Abstracts, vol. 82:69920 (1986).
Schilt, U. Overview of Viruses Relevant to Blood Transfusion, "Virus Inactivation in Plasma Products".
Heimburger, N., and Karges, H. E., Strategies to Produce Virus-safe Blood Derivates. "Virus Inactivation in Plasma Products".
Piszkiewicz, D. Thomas, W. Lieu, M. Y., Tse, D., and Sarno, L., Virus Inactivation by Heat Treatment of Lyophilized Coagulation Factor Concentrates, "Inactivation in Plasma Products".
Winkelman, L., Fedlman, P. A., and Evans, D. R., Severe Heat Treatment of Lyophilised Coagulation Factors, "Virus Inactivation Plasma Products".
McGill, M., Vittorio, N., Fugman, D., Transfusion (Abstraction Edition; the 36th AABB Annual Meeting), 1983, p. 414 (Abstr.).
McGill, M., Fugman, D. A., Vittorio, N., Darrow, C., Platelet Membrane Vesicles Reduced Microvascular Bleeding Times in Thrombocytopenic Rabbits, J. Lab. Clin. Clin. Med. 109;127, 1987.
Klein, E., Farber, S., Djersasi, I., Toch, R., Freeman, G., Arnold, P., The Preparation of and Clinical Administration of Lypholized Platelet Material to Children with Acute Leukemia and Aplastic Anemia, J. Pediatrict 49:517, 1956.
Alkjaersig, N., Abe, T., and Seeger, W. H., Purification and Quantitative Determination of Platelet Factor 3, Journal Unknown, May 1955.
Wu, V-Y, McCoy, L. E., Platelet Factor 3: Quantitation and Characterization, Thromb. Res. 11:581, 1977.
Sandberg, H., Andersson, L-O, Hoglund, S., Isolation and Characterization of Lipid-Protein Particles Containing Platelet Factor 3 Released from Human Platelets, BioChem J., 203, pp. 303-311 (1982).
Sandberg, H., Gellerbring, A-K, Anderson, L-O, Determination of Platelet Factor 3 in Whole Blood by a Chromogenic Peptide Substrate Assay, Thromb. Res. 18:871, 1980.
Nichols, W. L., Kaese S. E., Moore, S. E., Blood (68 (Suppl. 1): 300a (abstr.), 1986.
Tullis, J. L., Surgenor, D. M., Baudanza, P., Preserved Platelets: Their Preparation, Storage and Clinical Use, Blood 14:459, 1959.
Chao, F. C., Tullis, J. L., Alper, C. A., Glynne, R. J., Silbert, S. E., Alteration in Plasma Proteins and Platelet Functions with Aging and Cigarette Smoking in Healthy Men, Thrombos Haemostas, 47:459 1982.
Chao, F. C., Tullis, J. L., Tinch, R. J., Conneely, G. S., Baudanza, P. Platelet Phoresis by Discontinuous Centrification: Effective Collecting, Brit J. Haematol, 39:177, 1978.
Kahn, R. A., Allen, R. W., Baldassare, J., Alternate Sources and Substitutes for Therapeutic Blood Components, Blood 66:1, 1985.
Hjort, P. F., Perman, V., Cronkite, E. P., Fresh, Disintegrated Platelets in Radiation Thrombocytopenia: Correction of Prothrombin Consumption Without Correction of Bleeding, Proc. Soc. Expt. Biol Med. 102:31, 1959.
Firkin, B. G., Arimura, G., Harrington, W. J.: A Method for Evaluation the Hemostatic Effect of Various Agents in Thrombocytopenic Rats and Mice, Blood 15:388, 1960.
Jackson, D. P., Soronson, D. K., Cronkite, E. P., Bond, V. P., and Fliedner, T. M., Effectiveness of Transfusions of Fresh and Lyophilized Platelets in Controlling Bleeding Due to Thrombocytopenia, J. Clin. Invest., 38:1689-1697 (1959).
Zucker, M. B., Can Platelet Fragments Induce Hemostasis?, J. Lab. Clin. Med. 109:111, 1987.
Stefanini, M., Kistner, S., Use of Platelet Derivatives and Platelet Substitutes in the Management of Thrombocytopenic States, Clinical Research Proceedings, 5: pp. 151-152 (1957) (Abst).
Walsh, P. N., Schmaier, A. H., Platelet--Coagulant Protein Interactions, In Hemostatis and Thrombosis (Colman R. W., Hirsh J., Marder V. J., Salzman E. W., Eds), Kippincott, N.Y. 1987, p. 689.

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