Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-08-10
1993-09-21
Dentz, Bernard
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546 41, 546 90, 546116, C07D491052, C07D49122
Patent
active
052470890
ABSTRACT:
Compounds of Formula I ##STR1## are made in accordance with the following scheme: ##STR2## wherein R may be loweralkyl; R.sub.t may be H, loweralkyl, loweralkoxy, or halo: R.sub.2, R.sub.3, R.sub.4, and R.sub.5 may each independently be H, amino, hydroxy, loweralkyl, loweralkoxy, loweralkylthio, di(loweralkyl)amino, cyano, methylenedioxy, formyl, nitro, halo, trifluoromethyl, aminomethyl, azido, amido, hydrazino, or any of the twenty standard amino acids bonded to the A ring via the amino-nitrogen atom; Y is H and W and X are halogen. Also disclosed are novel processes for making starting materials for the scheme given above, and novel intermediates employed in these processes.
REFERENCES:
Grigg et al., Tetrahedron, 46, No. 11, pp. 4003-4018 (1990).
Portlock et al., J. Org. Chem., 38, No. 13, pp. 2351-2355 (1973).
Comins, Ph.D. Thesis, Univ. of New Hampshire, "The Synthesis of Analogs of Camptothecin", May pp. 25-29 (1977).
Baevsky Matthew F.
Comins Daniel L.
Dentz Bernard
North Carolina State University
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