Acetylenes disubstituted with a heteroaromatic group and a tetra

Details Acetylenes disubstituted with a heteroaromatic group and a tetra Acetylenes disubstituted with a heteroaromatic group and a tetra

1992-09-21

1993-09-21

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514448, 549 69, 549 70, 549 71, 549 77, 549 78, 549 79, 549 80, A61K 3138, C07D33336

Patent

active

052469620

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH or an ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative thereof, or --CHO or an acetal derivative thereof, or --COR.sub.1 or a ketal derivative thereof where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4; or a pharmaceutically acceptable salt thereof.

REFERENCES:
Klaus et al. Chem. Abstracts, vol. 108, No. 21; 186588z (1988).

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