Method for screening for osteoporosis

Details Method for screening for osteoporosis Method for screening for osteoporosis

1994-09-19

1996-08-13

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

436518, 436804, G01N 3353, G01N 33543

Patent

active

055455344

ABSTRACT:
A method for screening for osteoporosis comprising bone sialoprotein of mammals. Osteoporosis can be screened by bringing the body fluid sample collected from a living body into contact with the above-mentioned diagnostic agent to immunochemically detect the antibody which is present in the said sample and specifically reacts with the said diagnostic agent.

REFERENCES:
Kinne et al., "Keratan Sulfate Proteoglycan in Rabbit Compact Bone Is Bone Sialoprotien II", J. Biol. Chem., 262(21):10206-10211 (1987).
Somerman et al., "Expression of Attachment Proteins During Cementogenesis", J. Biol. Buccale, 14:207-214 (1990).
Saxne et al, "Increased Release of Bone Sialoprotein Into Synovial Fluid Reflects Tissue Destruction in Rheumatoid Arthritis", Arthritis & Rheumatism, 38(1):82-90 (1995).
Jilka et al., "Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6", Science, 257(5066):88-91 (1992).
Franzen et al., "Isolation and Characterization of Two Sialoproteins Presented Only in Bone Calcified Matrix", Biochem. J., 232:715-724 (1985).
Fisher et al., "Purification and Partial Characterization of Small Proteoglycans I and II, Bone Sialoproteins I and II, and Osteonectin from the Mineral Compartment of Developing Human Bone", J. Biol Chem., 262(20):9702-9708 (1987).
Fisher, L. W. et al., "Matrix Sialoprotein of Developing Bone", J. Biol. Chem., 258(20):12723-12727 (1983).
Ohnishi et al, "Purification, Characterization, and Studies on Biosynthesis of a 59-kDa Bone Sialic Acid-containing Protein (BSP) from Rat Mandible Using a Monoclonal Antibody", J. Biol. Chem., 266(22):14636-14645 (1991).
Chenu, et al., "Platelets Contribute to Circulating Levels of Bone Sialoprotein in Human", J. Bone Miner. Res., 7(1):47-54 (1992).
Fisher et al, J. Biol. Chem., 262(20): 9702-9708 (1987).

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