Method of imaging using encapsulated magnetite particles

Details Method of imaging using encapsulated magnetite particles Method of imaging using encapsulated magnetite particles

1995-04-13

1996-08-13

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnostic or in vivo test agent which contains an...

424 9321, 424450, 424498, 436173, A61B 5055

Patent

active

055453953

ABSTRACT:
Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

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