Preparation of optically active aliphatic carboxylic acids

Details Preparation of optically active aliphatic carboxylic acids Preparation of optically active aliphatic carboxylic acids

1992-01-24

1993-06-15

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

548572, 549499, 549 79, 560 10, 560 15, 560100, 560102, 560105, 560152, 560248, C07B 5700

Patent

active

052200531

ABSTRACT:
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding a mixture of the aliphatic carboxylic acid to the material formed by: (i) forming a solution comprising said racemic mixture of a C.sub.1 to C.sub.6 linear or branched aliphatic carboxylic acid and an organic or inorganic solvent; (ii) treating said solution with a chiral organic nitrogenous base; (iii) precipitating from the reaction solution formed in step (ii) a crystalline material comprised of the less soluble diastereomeric salt. The solution is admixed with the crystalline material for a time sufficient to cause an increase in the amount of the less soluble diastereomeric salt in the crystalline material.

REFERENCES:
patent: 4724102 (1988-02-01), Cannata et al.
patent: 4752417 (1988-06-01), Inoue et al.
patent: 4973745 (1990-11-01), Blaschke et al.

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