Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholiny

Details Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholiny Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholiny

Filed on

1991-08-21

Date issued

1993-06-15

Examiner

Gerstl, Robert

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

C07D27740

Type

Patent

Status

active

Patent number

052200310

Description

ABSTRACT:
An improved process for the preparation of [1S-(1R*,2S*,3R*) ]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[(1-c yclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide is described where the key intermediate, 3-(2-amino-4-thiazolyl)-L-alanine is converted without protecting the aminothiazole group to the desired compound, as well as valuable intermediates used in the process.

REFERENCES:
Search Report for Corresponding PCT Application PCT/US92/03146 (91992).
Chem. Abstracts, vol. 68, (1968) 12889--Silberg Bull. Soc. Chem. Fr. (1967) 2235-8--Silberg Referenced in Above Chem. Abstract.
Encyclopedia of Chemical Technology, 3rd Ed. vol. 2, pp. 308, 406, 407, 388 (1978).
Silberg, Chem. Ber. 97, 1767 (1964).

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