Inhibitor of tissue factor activity

Details Inhibitor of tissue factor activity Inhibitor of tissue factor activity

1992-02-05

1993-06-15

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

435 696, C07K 1500

Patent

active

052199940

ABSTRACT:
A sulfated glycoprotein with a molecular weight of approximately 45 kda inhibits the activation of tissue factor and thus inhibits the coagulation of blood. This glycoprotein can be used for treatment or prevention of intravascular clotting.

REFERENCES:
Broze et al. Proc. Natl. Acad. Sci. USA 84:1886-1890 (1987).
Wun et al. "Cloning and Characterization of a cDNA Coding for the Lipoprotein-associated Coagulation Inhibitor Shows That it Consists of Three Tandem Kunitz-type Inhibitory Domains" J. Biol. Chem. 263(13):6001-6004 (1988).
Colburn et al. "Enhanced Inhibition of Tissue Factor by the Extended Form of an Endothelial Cell Cell Glycoprotein (an Extrinsic Pathway Inhibitor)" J. Cell. Physiol. 140:320-326 (1991).
Hjort "Anti-convertin" Scand. J. Clin. Lab. Invest. vol. 9, Supple 27, pp. 76-97.

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